Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis
Wei Shi, Ziying Feng, Fanglian Chi, Jiaqi Zhou, Qianqian Qiu, Yuxuan Jiang, Shuang Chen, Yue Zhong, Huiting Jia, Wenlong Huang, Hai Qian
Topics & Concepts
ChemistryReceptor tyrosine kinaseTyrosine kinaseRAC1VacuoleCell growthCell biologyCancer researchCancer cellApoptosisIn vivoReceptorCancerBiochemistrySignal transductionCytoplasmBiologyGeneticsBiotechnologyPhagocytosis and Immune RegulationProtein Degradation and InhibitorsNeuroblastoma Research and Treatments