FLT3 targeting in the modern era: from clonal selection to combination therapies
Vanessa E. Kennedy, Catherine C. Smith
Abstract
Fms-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia (AML). Modern targeting of FLT3 with inhibitors has improved clinical outcomes and FLT3 inhibitors have been incorporated into the treatment of AML in all phases of the disease, including the upfront, relapsed/refractory and maintenance settings. This review will discuss the current understanding of FLT3 biology, the clinical use of FLT3 inhibitors, resistance mechanisms and emerging combination treatment strategies.
Topics & Concepts
Myeloid leukemiaHematologyMedicineFms-Like Tyrosine Kinase 3Tyrosine kinaseOncologyCancer researchInternal medicineGeneBiologyMutationGeneticsReceptorAcute Myeloid Leukemia ResearchChronic Myeloid Leukemia TreatmentsHistone Deacetylase Inhibitors Research