Cisplatin attenuates taste cell homeostasis and induces inflammatory activation in the circumvallate papilla
Wenwen Ren, Xudong Cha, Rui Xu, Tianyu Wang, Caiquan Liang, Janice Y. Chou, Xiujuan Zhang, Fengzhen Li, Shenglei Wang, Boyu Cai, Peihua Jiang, Hong Wang, Huanhai Liu, Yiqun Yu
Abstract
This study highlights the inhibitory effects of cisplatin on taste cell homeostasis and function, identifies critical genes and biological processes regulated by chemotherapy, and proposes potential therapeutic targets and strategy for taste dysfunction in cancer patients.
Topics & Concepts
CisplatinLingual papillaTaste receptorTasteApoptosisTaste budCell biologyCell growthCancer researchBiologyPharmacologyChemistryChemotherapyBiochemistryGeneticsBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function StudiesAdvanced Chemical Sensor Technologies