CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development
Etienne Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley Hoover, Mark Raffeld, Richard J. Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, N. B. Abraham, Kevin L. Bennewith, William W. Lockwood
Abstract
expression correlates with poor prognosis, immunosuppressive regulatory T cells, and alteration to CD8 effector function in lung adenocarcinoma patients. Our data support targeting CCL5 or CCL5 receptors on immune suppressive cells to prevent formation of an immune suppressive tumor microenvironment that promotes lung cancer progression and immunotherapy insensitivity.
Topics & Concepts
CCL5Tumor microenvironmentImmune systemCancer researchChemokineKRASLung cancerImmunotherapyCytokineImmunologyMedicineT cellCD8CancerBiologyIL-2 receptorOncologyInternal medicineColorectal cancerCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction