Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
Çiğdem Gelegen, Diana Cash, Katarina Ilić, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jon T. Brown, Svjetlana Kalanj Bognar, Samuel F. Cooke, К. Ray Chaudhuri, Clive Ballard, Paul T. Francis, Ivana Rosenzweig
Abstract
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.