Transforming Growth Factor β Signaling Promotes HIV-1 Infection in Activated and Resting Memory CD4 <sup>+</sup> T Cells
Lok Yan Yim, Ka Shing Lam, Tsz‐Yat Luk, Yufei Mo, Xiaofan Lu, Jinlin Wang, Ka‐Wai Cheung, Grace Lui, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Thomas Tsz-Kan Lau, Chiu Bong Ngan, Dongyan Zhou, Yik Chun Wong, Zhiwu Tan, Li Liu, Hao Wu, Tong Zhang, Shui Shan Lee, Zhiwei Chen
Abstract
T cells are important latency reservoirs. Increased infection of these cells mediated by TGF-β will promote latency reservoir establishment during early infection. This study, therefore, highlighted the potential use of TGF-β blockade as a supplementary regimen with cART in acute patients to reduce viral latency.
Topics & Concepts
BiologyCXCR3ImmunologyC-C chemokine receptor type 7ChemokineDownregulation and upregulationChemokine receptorCytotoxic T cellTransforming growth factorCell biologyImmune systemIn vitroGeneBiochemistryHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology