Cranberry-Derived Proanthocyanidins Potentiate β-Lactam Antibiotics against Resistant Bacteria
Mathias Gallique, Kuan Wei, Vimal B. Maisuria, Mira Okshevsky, Geoffrey A. McKay, Dao Nguyen, Nathalie Tufenkji
Abstract
and staphylococci compromises the effectiveness of β-lactam-based therapy. By acquisition of ESBLs, MBLs, or PBPs, it is highly likely that bacteria may become completely resistant to the most effective β-lactam agents in the near future. In this study, we described a natural extract rich in proanthocyanidins which exerts adjuvant properties by interfering with two different resistance mechanisms. By their broad-spectrum inhibitory ability, cranberry-extracted proanthocyanidins could have the potential to enhance the effectiveness of existing β-lactam agents.
Topics & Concepts
LactamBacteriaEnterobacteriaceaeMicrobiologyAntibioticsBiologyChemistryEscherichia coliBiochemistryStereochemistryGeneGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance