Lewis acid-catalyzed double addition of indoles to ketones: synthesis of bis(indolyl)methanes with all-carbon quaternary centers
Si On Lee, Si On Lee, Jeongin Choi, Seunghoon Kook, Sarah Yunmi Lee, Sarah Yunmi Lee
Abstract
We report herein a Lewis acid-catalyzed nucleophilic double-addition of indoles to ketones under mild conditions. This process occurs with various ketones ranging from dialkyl ketones to diaryl ketones, thereby providing access to an array of bis(indolyl)methanes bearing all-carbon quaternary centers, including tetra-aryl carbon centers. The products can be transformed into bis(indole)-fused polycyclics and bis(indolyl)alkenes.
Topics & Concepts
Quaternary carbonCatalysisChemistryLewis acids and basesCarbon fibersOrganic chemistryMedicinal chemistryEnantioselective synthesisMaterials scienceComposite numberComposite materialSynthesis of Indole DerivativesChemical Synthesis and ReactionsBioactive natural compounds