Different members of the APOBEC3 family of DNA mutators have opposing associations with the landscape of breast cancer.
Mariko Asaoka, Santosh K. Patnaik, Takashi Ishikawa, Kazuaki Takabe
Abstract
expression in tumors, respectively. These observations on opposing associations with breast cancer of different APOBEC3s highlight the contrasting roles of these enzymes, promoting cancer through mutagenesis while antagonizing it through immune response.
Topics & Concepts
Breast cancerBiologyImmune systemCancer researchAPOBECCancerCD8GeneImmunologyGeneticsGenomeFerroptosis and cancer prognosisCancer Genomics and DiagnosticsEpigenetics and DNA Methylation