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Regioselective Disulfide-Catalyzed Photocatalytic Oxidative Cleavage of 1-Arylbutadienes to Cinnamaldehydes

Rodney A. Fernandes, P. B. Sunil Kumar, Amit Bhowmik, Dnyaneshwar A. Gorve

2022Organic Letters15 citationsDOI

Abstract

This work discloses a simple, efficient, and environmentally benevolent disulfide-catalyzed photocatalytic regioselective oxidative cleavage of 1-arylbutadienes to cinnamaldehydes. This methodology illustrates mild reaction conditions, ambient temperature, excellent regioselectivity, and compatibility with wide range of functional groups (38 examples). The method gains significance, as few reports with limited substrate scope are available for such excellent photocatalytic oxidative cleavage of conjugated dienes.

Topics & Concepts

RegioselectivityChemistryOxidative cleavagePhotocatalysisOxidative phosphorylationConjugated systemCatalysisCleavage (geology)Combinatorial chemistryDisulfide bondOrganic chemistryBiochemistryGeotechnical engineeringEngineeringPolymerFracture (geology)Chemical Synthesis and ReactionsOxidative Organic Chemistry ReactionsSulfur-Based Synthesis Techniques
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