Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India
Samantha L Huey, Lingjing Jiang, Marcus W. Fedarko, Daniel McDonald, Cameron Martino, Farhana Ali, David G. Russell, Shobha Udipi, Aparna Thorat, Varsha Thakker, Padmini Ghugre, R.D. Potdar, Harsha Chopra, Kripa Rajagopalan, Jere D. Haas, Julia L. Finkelstein, Rob Knight, Saurabh Mehta
Abstract
The impact of comprehensive nutritional status, defined as growth, nutritional blood biomarkers, dietary intakes, and feeding practices, on the gut microbiome in children living in low-resource settings has remained underreported in microbiome research. Among undernourished children living in urban slums of Mumbai, India, we observed a high relative abundance of Proteobacteria , a phylum including many potentially pathogenic species similar to the composition in preterm infants, suggesting immaturity of the gut, or potentially a high inflammatory burden. We found head circumference, fat and iron intake, and current breastfeeding were positively associated with microbial diversity, while hemoglobin and weight for length were associated with lower diversity. Findings suggest that examining comprehensive nutrition is critical to gain more understanding of how nutrition and the gut microbiota are linked, particularly in vulnerable populations such as children in urban slum settings.