Ubiquitin D Promotes Progression of Oral Squamous Cell Carcinoma via NF-Kappa B Signaling
An Song, Yi Wang, Feng Jiang, Enshi Yan, Junbo Zhou, Jinhai Ye, Hongchuang Zhang, Xu Ding, Gang Li, Yunong Wu, Yang Zheng, Xiaomeng Song, Xiaomeng Song
Abstract
. We found that UBD was upregulated in human OSCC tissues and cell lines and was associated with clinical and pathological features of patients. Moreover, the overexpression of UBD promoted the proliferation, migration and invasion of OSCC cells; however, the knockdown of UBD exerted the opposite effects. In this study, our results also suggested that UBD promoted OSCC progression through NF-κB signaling. Our findings indicated that UBD played a critical role in OSCC and may serve as a prognostic biomarker and potential therapeutic target for OSCC treatment.
Topics & Concepts
Cancer researchDownregulation and upregulationImmunohistochemistryCell growthWestern blotGene knockdownUbiquitinNF-κBBiologyCell cultureSignal transductionMedicinePathologyCell biologyGeneticsGeneBiochemistryUbiquitin and proteasome pathwaysNF-κB Signaling PathwaysImmunotherapy and Immune Responses