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Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3)

Abdellah Yamani, Daria Zdżalik-Bielecka, Joanna Lipner, Aleksandra Stańczak, Natalia Piórkowska, Paulina Seweryna Stańczak, Patrycja Olejkowska, Joanna Hucz‐Kalitowska, Marta Magdycz, Karolina Dzwonek, Krzysztof Dubiel, Monika Lamparska‐Przybysz, Delfina Popiel, Jerzy Pieczykolan, Maciej Wieczorek

2020European Journal of Medicinal Chemistry45 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryFibroblast growth factor receptorBenzimidazolePyrazoleReceptorFibroblast growth factorFibroblast growth factor receptor 3Fibroblast growth factor receptor 1Combinatorial chemistryBiochemistryPharmacologyStereochemistryOrganic chemistryMedicineFibroblast Growth Factor ResearchKruppel-like factors researchEosinophilic Disorders and Syndromes
Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1–3) | Litcius