A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva
N. Sathishkumar, Jose Gilberto Camacho Valenzuela, Nguyen H. Le, Anthony K. C. Yong, Martín A. Rossotti, Joshua Dahmer, Alexandros A. Sklavounos, Martin Plante, D. Brassard, Lidija Malic, Anna N. Moraitis, Ruzica Biga, Imane El Idrissi, Jamshid Tanha, Jean Labrecque, Teodor Veres, Aaron R. Wheeler
Abstract
= 14) showed strong correlation with PCR and commercial ELISA, achieving 100% sensitivity and 100% specificity for infection detection and 100% sensitivity with 91.7% and 90.9% specificity for host IgG and IgA, respectively. These results highlight potential applications for the new system as a portable diagnostic tool for outbreak surveillance and public health management, as a step toward preparing for the next global pandemic.
Topics & Concepts
SalivaImmunityImmune systemImmunologyMicrofluidicsImmune statusVirologyMedicineMaterials scienceInternal medicineNanotechnologyBiosensors and Analytical DetectionMicrofluidic and Bio-sensing TechnologiesAdvanced biosensing and bioanalysis techniques