A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy
Mengzhu Zhang, Xiaohan Qin, Zhipeng Zhao, Qian Du, Qian Li, Yue Jiang, Yuxia Luan
Abstract
the genetic blockade effect. The RCH NPs thus demonstrated superior therapeutic effects on tumors, thanks to self-amplifying ferroptotic immunotherapy. Our work offers a conceptually innovative strategy for harnessing ferroptosis against tumors.
Topics & Concepts
JanusReversingCancer researchNanotechnologyCell biologyBiologyMaterials scienceComposite materialExtracellular vesicles in diseaseFerroptosis and cancer prognosisNanoplatforms for cancer theranostics