A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment
Xiangyan Xie, Ruijuan Xu, Hongyan Ouyang, Shiqiao Tan, Chuan Fei Guo, Xingqi Luo, Yuanjie Xie, Di Wu, Xiangyu Dong, Jinrong Wu, Yi Wang, Lijuan Zhao
Abstract
experiments show that the hydrogel possesses good biocompatibility similar to pure PHEMA hydrogels. In addition, the hydrogel releases estradiol continuously and stably, and exhibits a good therapeutic effect in promoting the proliferation of endometrial cells and inhibiting the progression of fibrosis. Therefore, the combinational advantages make the present hydrogel very promising in IUA treatment.
Topics & Concepts
BiocompatibilitySelf-healing hydrogelsMaterials scienceMethacrylateCovalent bondAdhesionScaffoldDrug deliveryBiomedical engineeringNanotechnologyPolymer chemistryComposite materialChemistryPolymerOrganic chemistryCopolymerMedicineMetallurgySurgical Sutures and AdhesivesGynecological conditions and treatmentsIntestinal and Peritoneal Adhesions