Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production
Hozaifa Metwally, Toshio Tanaka, Songling Li, Gyanu Parajuli, Sujin Kang, Hamza Hanieh, Shigeru Hashimoto, Jaya Prakash Chalise, Yohannes Gemechu, Daron M. Standley, Tadamitsu Kishimoto
Abstract
mRNA stabilization. Thus, our study provides a potential mechanism for how TLR4 endocytosis might regulate proinflammatory cytokine production.
Topics & Concepts
STAT1PhosphorylationProinflammatory cytokineCell biologyTLR4BiologyEndocytosisSignal transductionReceptorImmunologyBiochemistryInflammationinterferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions