Clinic-on-a-Needle Array toward Future Minimally Invasive Wearable Artificial Pancreas Applications
Omri Heifler, Ella Borberg, Nimrod Harpak, Marina Zverzhinetsky, Vadim Krivitsky, Itay Gabriel, Victor Fourman, Dov Sherman, Fernando Patolsky
Abstract
continuous glucose monitoring of healthy human subjects. Furthermore, minor adjustments to the fabrication technique allow the on-chip integration of microinjection needle elements, which can ideally be used as a drug delivery system. Preliminary experiments on a mice animal model successfully demonstrated the single-chip capability to both monitor glucose levels as well as deliver insulin. By that, we hope to provide in the future a cost-effective and reliable wearable personalized clinical tool for patients and a strong tool for research, which will be able to perform direct monitoring of clinical biomarkers in the ISF as well as synchronized transdermal drug delivery by this single-chip multifunctional platform.