No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry
Maria Pia Campagna, Eva Havrdová, Dana Horáková, Guillermo Izquierdo, Fuencisla Matesanz, Sara Eichau, Jeannette Lechner‐Scott, Bruce Taylor, Maria-Isabel García-Sanchéz, Antonio Alcina, Anneke van der Walt, Helmut Butzkueven, Vilija Jokubaitis
Abstract
BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. RESULTS: > 0.05). CONCLUSION: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.