Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells
Jingjing Deng, Baogeng Hou, Xiaohan Hou, Yuxin Chen, Tao Zhang, Hua Chen, Yuanze Wang, Xiaoyang Li
Topics & Concepts
ChemistryBenzamideHistone deacetylasePI3K/AKT/mTOR pathwayAcetylationhERGPharmacologyProtein kinase BApoptosisBiochemistryHistoneStereochemistryBiologyBiophysicsPotassium channelGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsSynthetic Organic Chemistry Methods