Circulation of an Artemisinin-Resistant Malaria Lineage in a Traveler Returning from East Africa to France
Romain Coppée, Justine Bailly, Véronique Sarrasin, Bertin Vianou, Boris Enock Zinsou, Edith Mazars, Hugues Georges, Samia Hamane, Rose Anne Lavergne, Éric Dannaoui, Betty Balikagala, Naoyuki Fukuda, Emmanuel Igwaro Odongo-Aginya, Toshihiro Mita, Sandrine Houzé, Jérôme Clain
Abstract
A returned traveler to Uganda presented with a Plasmodium falciparum kelch13 A675V mutant infection that exhibited delayed clearance under artesunate therapy. Parasites were genetically related to recently reported Ugandan artemisinin-resistant A675V parasites. Adequate malaria prevention measures and clinical and genotypic surveillance are important tools to avoid and track artemisinin resistance.
Topics & Concepts
ArtemisininArtesunateMedicineMalariaPlasmodium falciparumDrug resistancePiperaquineProtozoal diseaseVirologyIntensive care medicineImmunologyMicrobiologyBiologyMalaria Research and ControlTravel-related health issuesMosquito-borne diseases and control