SARS-CoV-2 Spike-Specific T-Cell Responses in Patients With B-Cell Depletion Who Received Chimeric Antigen Receptor T-Cell Treatments
Kalpana Parvathaneni, Kyabeth Torres-Rodriguez, Wenzhao Meng, Wei‐Ting Hwang, Noelle V. Frey, Ali Naji, Vijay Bhoj
Abstract
This cohort study examines the ability of patients receiving chimeric antigen receptor T-cell treatments to mount T-cell immunity in response to messenger RNA vaccines for severe acute respiratory syndrome coronavirus 2 despite substantial B-cell depletion.
Topics & Concepts
MedicineChimeric antigen receptorReceptorImmunologyAntigenCellT cellB cellVirologyImmune systemInternal medicineAntibodyBiologyGeneticsCAR-T cell therapy researchSARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune Responses