Recent progress in topoisomerase inhibitors as anticancer agents: Research and design strategies for Topo I and II inhibitors via structural optimization
G. D. Shen, Shihao Li, Yu Zhu, Zheng Xu, Xuan Liu, Chen Lv, Zhihua Xing, Linlin Cui, Wenlan Li
Topics & Concepts
TopoisomeraseTopoisomerase inhibitorChemistryEnzymeComputational biologyDNACancerCancer cellCell growthPharmacologyBiochemistryCancer researchEnzyme inhibitorCancer therapyDrugDNA damageBiologyDrug discoveryTumor cellsCancer therapeutics and mechanismsSynthesis and biological activityBioactive Compounds and Antitumor Agents