Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using AgCF<sub>3</sub>
Yukiko Karuo, Tatsuto Hayashi, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote
Abstract
A mild and convenient reaction for oxidative trifluoromethylation of terminal alkenes was developed using in situ generated AgCF3 in the presence of a copper catalyst. The reaction proceeded under an air atmosphere to afford trifluoromethylated allylic compounds in moderate to good yield. This reaction, with no need for highly hygroscopic or corrosive reagents, features not only a simple operation but also various functional group tolerances.
Topics & Concepts
TrifluoromethylationChemistryAllylic rearrangementReagentYield (engineering)CatalysisCopperOxidative phosphorylationOrganic chemistryFunctional groupCombinatorial chemistryMetallurgyTrifluoromethylMaterials scienceBiochemistryPolymerAlkylFluorine in Organic ChemistryInorganic Fluorides and Related Compounds