DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
Zhe Hong, Wei Zhang, Donglin Ding, Zhenlin Huang, Yuqian Yan, William Cao, Yunqian Pan, Xiaonan Hou, Saravut J. Weroha, R. Jeffrey Karnes, Dejie Wang, Qiang Wu, Denglong Wu, Haojie Huang
Topics & Concepts
TMPRSS2BiologyCancer researchErgDNA damageFusion geneProstate cancerWee1PTENCarcinogenesisUbiquitin ligaseUbiquitinCell biologyCancerSignal transductionCell cycleGeneticsGeneInternal medicineDNAPI3K/AKT/mTOR pathwayBiochemistryMedicineDiseaseRetinalCyclin-dependent kinase 1Infectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsProstate Cancer Treatment and Research