Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin
Amita Vaidya, Nadia Ayat, Megan Buford, Helen Wang, Aman Shankardass, Yiqing Zhao, Hannah Gilmore, Zhenghe Wang, Zheng‐Rong Lu
Abstract
EDB-FN is a promising molecular marker for assessing drug resistance. MRMI of EDB-FN with MT218 at a significantly reduced dose can facilitate effective non-invasive assessment and treatment response monitoring of drug-resistant CRC, highlighting its translational potential for active surveillance and management of CRC and other malignancies.
Topics & Concepts
Colorectal cancerImmunohistochemistryFibronectinCancer researchExtracellular matrixWestern blotMedicineCancerMolecular imagingPathologyChemistryInternal medicineBiologyGeneIn vivoBiochemistryBiotechnologyCell Adhesion Molecules ResearchNanoparticle-Based Drug DeliveryRadiomics and Machine Learning in Medical Imaging