Neuroinduction and neuroprotection co-enhanced spinal cord injury repair based on IL-4@ZIF-8-loaded hyaluronan–collagen hydrogels with nano-aligned and viscoelastic cues
Nini Xin, Xiaoyin Liu, Suping Chen, Yusheng Zhang, Dan Wei, Jing Sun, Liangxue Zhou, Chengheng Wu, Hongsong Fan
Abstract
We developed a nano-aligned and viscoelastic hydrogel matrix embedded with IL-4@ZIF-8. This biomimetic hydrogel combining neuroinductive cues and neuroprotective cues showed promising prospects in SCI repair.
Topics & Concepts
Self-healing hydrogelsNeuroprotectionMaterials scienceViscoelasticityNano-Spinal cord injuryBiomedical engineeringHyaluronic acidSpinal cordComposite materialMedicinePolymer chemistryAnatomyNeurosciencePharmacologyBiologySpinal Cord Injury ResearchNerve injury and regenerationAortic Disease and Treatment Approaches