Fragment-to-Lead Medicinal Chemistry Publications in 2021
Louise Walsh, Daniel A. Erlanson, Iwan J. P. de Esch, Wolfgang Jahnke, Andrew Woodhead, Ella Wren
Abstract
This Perspective is the seventh in an annual series that summarizes successful Fragment-to-Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles published in 2021 is provided, and features such as target class, screening methods, and ligand efficiency are discussed, both for the 2021 examples and for the combined examples over the years 2015-2021. In addition, trends and new developments in the field are summarized. In particular, the use of structural information in fragment-based drug discovery is discussed.
Topics & Concepts
ChemistryFragment (logic)Lead (geology)Computational biologyData scienceMedicinal chemistryComputer scienceAlgorithmBiologyGeomorphologyGeologyComputational Drug Discovery MethodsClick Chemistry and ApplicationsChemical Reactions and Isotopes