Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling
Shenxin Zeng, Yuyuan Jin, Heye Xia, Yanwei Shang, Ying‐Zhou Li, Zunyuan Wang, Wenhai Huang
Topics & Concepts
T-cell receptorChemistryCell biologyT cellKinaseComputational biologyCancer researchImmune systemBiologyBiochemistryImmunologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisMultiple Myeloma Research and Treatments