Regioselective aromatic <i>O</i>-demethylation with an artificial P450BM3 peroxygenase system
Yihui Jiang, Chunlan Wang, Nana Ma, Jie Chen, Chuanfei Liu, Fang Wang, Jiakun Xu, Zhiqi Cong
Abstract
Highly regioselective <italic>O</italic>-demethylation of aromatic ethers related to the bioconversion of lignin was achieved by the H<sub>2</sub>O<sub>2</sub>-dependent engineered P450BM3 enzymes with assistance of a dual-functional small molecule (DFSM) for the first time.
Topics & Concepts
RegioselectivityBioconversionDemethylationChemistryBiocatalysisLigninMoleculeStereochemistryCombinatorial chemistryCatalysisOrganic chemistryBiochemistryReaction mechanismGeneDNA methylationGene expressionFermentationPlant-derived Lignans Synthesis and BioactivityAlkaloids: synthesis and pharmacologyAsymmetric Hydrogenation and Catalysis