The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway
Shuangyan Lin, Mingyuan Zhao, Yanbo Lv, Genxiang Mao, Shiping Ding, Fang Peng
Abstract
expression regulators. Then, five lncRNAs were predicted to potentially bind to the four miRNAs. Combination of the results from expression, survival, correlation analysis and functional experiments analysis demonstrated the link between lncRNA GATA3-AS1/miR-495-3p/CENPU axis and prognosis of breast cancer. In conclusion, CENPU could be involved in cell cycle progression through PLK1 signaling pathway.
Topics & Concepts
Breast cancermicroRNAGATA3Cancer researchPLK1Breast carcinomaBiologyGeneCancerSignal transductionGene expressionCell cycleOncologyInternal medicineMedicineTranscription factorGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerMicroRNA in disease regulation