Toll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection
Bradley S. Hollidge, Courtney A. Cohen, Justice Akuoku Frimpong, Catherine V. Badger, John M. Dye, Connie S. Schmaljohn
Abstract
mice. These data demonstrate the critical role of TLR4 in mediating BBB permeability and disease in C3H mice during VEEV TC-83 infection, which suggests that TLR4 is a potential target for the development of therapeutics for VEEV.
Topics & Concepts
Venezuelan equine encephalitis virusBiologyImmunologyBlood–brain barrierTLR4AlphavirusEncephalitisImmune systemVirologyVirusCentral nervous systemEndocrinologyMosquito-borne diseases and controlVibrio bacteria research studiesNeonatal and fetal brain pathology