Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis

Abstract

Computational modeling is used to predict cardiovascular responses to altered gravitational environments. However, considerable variation between subjects and model complexity makes accurate parameter assignment for individuals challenging. This computational effort studies sensitivity in cardiovascular model outcomes due to varying parameters across a normal physiological range. This allows determination of which parameters have the largest influence on outcomes, i.e., which parameters must be most carefully selected to give accurate predictions of individual responses.

Topics & Concepts