AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling
Guorong Deng, Li-Yi Zhang, Chunliang Wang, Shuang Wang, Jiacheng Xu, Jing Dong, Qi Kang, Xia Zhai, Zhao Yun, Zhonggui Shan
Topics & Concepts
Rage (emotion)BMPR2Mesenchymal stem cellEndoglinTransforming growth factorEpithelial–mesenchymal transitionTransforming growth factor betaCalcificationMedicineCancer researchInternal medicineCardiologyCell biologyBone morphogenetic proteinBiologyPathologyGeneNeuroscienceGeneticsMetastasisCancerCD34Stem cellCardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesCardiovascular Function and Risk Factors