Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang, David W. White, Stefan Größ, Bryson D. Bennett, Mark Bittinger, Edward M. Driggers, Valeria R. Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C. Keenan, Kevin M. Marks, Robert M. Prins, Patrick S. Ward, Katharine Yen, Linda M. Liau, Joshua D. Rabinowitz, Lewis C. Cantley, Craig B. Thompson, Matthew G. Vander Heiden, Shinsan M. Su
Topics & Concepts
Isocitrate dehydrogenaseIDH1Oxidative decarboxylationEnzymeMutationBiochemistryBiologyCancer researchChemistryGeneCancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentEnzyme Structure and Function