Litcius/Paper detail

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Stefan Größ, Bryson D. Bennett, Mark Bittinger, Edward M. Driggers, Valeria R. Fantin, Hyun Gyung Jang, Shengfang Jin, Marie C. Keenan, Kevin M. Marks, Robert M. Prins, Patrick S. Ward, Katharine Yen, Linda M. Liau, Joshua D. Rabinowitz, Lewis C. Cantley, Craig B. Thompson, Matthew G. Vander Heiden, Shinsan M. Su

2009Nature4,133 citationsDOIOpen Access PDF

Topics & Concepts

Isocitrate dehydrogenaseIDH1Oxidative decarboxylationEnzymeMutationBiochemistryBiologyCancer researchChemistryGeneCancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentEnzyme Structure and Function
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate | Litcius