Litcius/Paper detail

Visible-Light-Induced Dual C(sp<sup>3</sup>)–H Bond Functionalization of Tertiary Amine via Hydrogen Transfer to Carbene and Subsequent Cycloaddition

Kaixiu Luo, Yongqiang Zhao, Zhiliang Tang, Weina Li, Jun Lin, Yi Jin

2022Organic Letters19 citationsDOI

Abstract

)-H bond functionalization of a tertiary amine through hydride-transfer-induced dehydrogenation, followed by cycloaddition, using an easily preparable diazoester as a new type hydride-acceptor precursor under mild, redox-neutral conditions. With carbene as a hydrogen acceptor, this method was demonstrated by the preparation of a broad range of functionalized isoxazoldines in moderate to good yields.

Topics & Concepts

ChemistryCarbeneSurface modificationCycloadditionAmine gas treatingPhotochemistryHydrogen bondVisible spectrumMedicinal chemistryMoleculeOrganic chemistryCatalysisOptoelectronicsPhysical chemistryPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry