Targeting NAD+ metabolism of hepatocellular carcinoma cells by lenvatinib promotes M2 macrophages reverse polarization, suppressing the HCC progression
Qingcan Sun, Mengying Shen, Subin Zhu, Yanxia Liao, Dongyan Zhang, Jingyuan Sun, Ze-Qin Guo, Leyuan Wu, Lushan Xiao, Li Liu
Topics & Concepts
LenvatinibCancer researchNAD+ kinaseImmune systemMolecular biologyChemistryHepatocellular carcinomaBiologyBiochemistrySorafenibImmunologyEnzymeImmune cells in cancerEpigenetics and DNA MethylationCancer Immunotherapy and Biomarkers