Modeling Tubercular ESX-1 Secretion Using Mycobacterium marinum
Alexandra E. Chirakos, Ariane Balaram, William H. Conrad, Patricia A. Champion
Abstract
Pathogenic mycobacteria cause chronic and acute diseases ranging from human tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute and chronic human tuberculosis. Environmentally acquired nontubercular mycobacteria (NTM) cause chronic disease in humans and animals. Not surprisingly, NTM and M. tuberculosis often use shared molecular mechanisms to survive within the host. The ESX-1 system is a specialized secretion system that is essential for virulence and is functionally conserved between M. tuberculosis and Mycobacterium marinum .
Topics & Concepts
Mycobacterium marinumTuberculosisBiologyMycobacterium tuberculosisVirulenceMicrobiologyMycobacteriumSecretionMycobacterium tuberculosis complexESAT-6VirologyImmunologyBacteriaMedicineGenePathologyGeneticsBiochemistryMycobacterium research and diagnosisTuberculosis Research and EpidemiologyAntibiotic Resistance in Bacteria