The Fall in Antibody Response to SARS-CoV-2: a Longitudinal Study of Asymptomatic to Critically Ill Patients Up to 10 Months after Recovery
Maddalena Peghin, Maria De Martino, Martina Fabris, Alvisa Palese, Erica Visintini, Elena Graziano, Valentina Gerussi, Giulia Bontempo, Federica D’Aurizio, Alessia Biasotto, Assunta Sartor, Corrado Pipan, Stefania Marzinotto, Francesco Curcio, Emilio Bouza, Miriam Isola, Carlo Tascini
Abstract
The aim of this study was to assess the long-term dynamics and factors associated with the serological response against the severe acute respiratory syndrome coronavirus 2 after primary infection. A prospective longitudinal study was conducted with monthly serological follow-up during the first 4 months, and then at 6, 8, and 10 months after the disease onset of all recovered adult in- and outpatients with coronavirus disease 2019 (COVID-19) attending Udine Hospital (Italy) during the first wave (from March to May 2020).