Quality by design (QbD) approach to develop fast-dissolving tablets using melt-dispersion paired with surface-adsorption method: formulation and pharmacokinetics of flurbiprofen melt-dispersion granules
Sateesh Kumar Vemula, Bhaskar Daravath, Michael A. Repka
Topics & Concepts
DissolutionDispersion (optics)Central composite designAdsorptionChromatographyDissolution testingMaterials scienceBioavailabilityResponse surface methodologySolubilityPharmacokineticsDifferential scanning calorimetryFlurbiprofenAngle of reposeChemistryComposite materialOrganic chemistryPharmacologyThermodynamicsBiopharmaceutics Classification SystemOpticsMedicinePhysicsDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAnalytical Methods in Pharmaceuticals