Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments
Robert M. Califf, Adrian F. Hernandez, Martin Landray
Abstract
This Viewpoint discusses the role of observational study designs and data in the rapid stand-up of an evidence base for managing the COVID-19 pandemic, proposing ways to position observational research as a foundation for rapid follow-on randomized evaluation without premature overinterpretation of its findings
Topics & Concepts
Observational studyMedicineFoundation (evidence)Randomized controlled trialPandemicCoronavirus disease 2019 (COVID-19)Intensive care medicineSurgeryPathologyDiseaseLawPolitical scienceInfectious disease (medical specialty)Advanced Causal Inference TechniquesStatistical Methods and InferenceHealth Systems, Economic Evaluations, Quality of Life