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Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion

Lucas F. daSilva, Simon Senan, Judith F. Kribelbauer, Z. Patel, Lithin Karmel Louis, Aniketh Janardhan Reddy, Sameer Gabbita, Jonathan D. Rosen, Zach Nussbaum, Cesar Miguel Valdez Cordova, Aaron Wenteler, Noah Weber, Tin M. Tunjic, Martino Mansoldo, Talha Ahmad Khan, Gue‐Ho Hwang, Vincent Gardeux, David T. Humphreys, Cameron Smith, Matei Bejan, Peter Bromley, Will Connell, Bart Deplancke, Michael I. Love, Emily S. Wong, Wouter Meuleman, Luca Pinello

2025Nature Genetics8 citationsDOIOpen Access PDF

Topics & Concepts

Generative grammarBiologyComputational biologySynthetic biologyGenomicsRegulatory sequenceComputational genomicsComputer scienceFunctional genomicsArtificial intelligenceGene regulatory networkGeneRegulation of gene expressionCis-regulatory moduleTranscription factorGenerative modelMachine learningSequence (biology)GenomeTranscription (linguistics)DNA sequencingGrammarGenome engineeringGene expressionEndogenyDNADNA binding siteGenomics and Chromatin DynamicsGene Regulatory Network AnalysisRNA and protein synthesis mechanisms
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion | Litcius