DMSO-assisted environmentally benign synthesis of benzo[<i>c</i>]-chromeno[4,3,2-<i>gh</i>]phenanthridines by remote oxidative hetero cross-coupling cyclization and aromatization reaction
Sabina Yashmin, Rashid Ali, Santa Mondal, Abu T. Khan
Abstract
-quinone methide intermediate followed by an electrocyclic ring closure reaction. The aromatization of the cyclohexane ring is achieved by sequential H shift, hydroxylation, and elimination reaction. DMSO-assisted concomitant cyclization and aromatization reactions are also disclosed for the first time.
Topics & Concepts
AromatizationChemistryPhenanthridineHydroxylationCyclohexaneQuinone methideRing (chemistry)Oxidative phosphorylationMedicinal chemistryCatalysisCoupling reactionStereochemistryPhotochemistryOrganic chemistryQuinoneEnzymeBiochemistrySynthesis of Indole DerivativesAxial and Atropisomeric Chirality SynthesisBioactive Compounds and Antitumor Agents