Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway
Marwa El-Sayed El-Shamarka, Ayman E. El-Sahar, Muhammed A. Saad, Naglaa Assaf, Rabab H. Sayed
Topics & Concepts
NeuroprotectionNeurotoxicityAdenosine A2A receptorTropomyosin receptor kinase BInosineNeurotrophic factorsEndocrinologyMAPK/ERK pathwayCREBInternal medicineNeuroinflammationPharmacologyBrain-derived neurotrophic factorChemistryMedicineKinaseAdenosineBiochemistryReceptorAgonistInflammationToxicityAdenosine receptorTranscription factorGeneGenetic Neurodegenerative DiseasesNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms