Direct arylation of alkyl fluorides using <i>in situ</i> mechanochemically generated calcium-based heavy Grignard reagents
Pan Gao, Julong Jiang, Yamato Fukuzawa, Satoshi Maeda, Koji Kubota, Hajime Ito
Abstract
Here, we report the reaction of calcium-based heavy Grignard reagents, which are easily generated by a mechanochemical method, with unactivated alkyl fluorides to produce the arylated products in moderate to good yields.
Topics & Concepts
AlkylReagentCalciumIn situGrignard reagentChemistryMaterials scienceOrganic chemistryFluorine in Organic ChemistryCatalytic Cross-Coupling ReactionsChemical Reactions and Isotopes