Molecular biology insights into levofloxacin-loaded ZnO nanoparticles: a potent strategy against MDR <i>Acinetobacter baumannii</i>
Mais Emad Ahmed, Ahmed Qassim Al-Awadi, Hussein S. Mohamed
Abstract
. Mechanistic studies revealed that ZnO-NPs induce membrane lipid peroxidation, elevate malondialdehyde and reactive oxygen species (ROS) levels, and cause DNA damage, protein denaturation, and membrane leakage in bacterial cells. These results indicate that biosynthesized ZnO-NPs, especially when conjugated with antibiotics, exhibit significant antimicrobial activity against multidrug-resistant pathogens, highlighting their potential as alternative therapeutic agents in addressing antibiotic resistance.
Topics & Concepts
Acinetobacter baumanniiLevofloxacinAcinetobacterMicrobiologyMultiple drug resistanceAntibiotic resistanceMulti drug resistantAntibioticsChemistryBiologyBacteriaGeneticsPseudomonas aeruginosaAntibiotic Resistance in BacteriaInhalation and Respiratory Drug DeliveryAntibiotic Use and Resistance