Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with <i>in vitro</i> antitumor activity towards non-small lung cancer
Esraa A. Abdelsalam, Amer Ali Abd El‐Hafeez, Wagdy M. Eldehna, Mahmoud A. El Hassab, Hala Mohamed M. Marzouk, Mahmoud M. Elaasser, Nageh A. Abou Taleb, Kamilia M. Amin, Hatem A. Abdel‐Aziz, Pradipta Ghosh, Sherif Hammad
Abstract
induce G2/M cell cycle arrest and apoptosis and inhibit migration in A549 cancerous cells.
Topics & Concepts
GefitinibIC50A549 cellApoptosisLung cancerIn vitroCancer researchChemistryInhibitory postsynaptic potentialCell cultureTyrosine kinasePharmacologyKinaseEpidermal growth factor receptorMedicineBiologyReceptorBiochemistryInternal medicineGeneticsSynthesis and biological activityCancer Mechanisms and TherapyLung Cancer Treatments and Mutations