PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
Rachel Ambler, Grace L. Edmunds, Sin Lih Tan, Silvia Cirillo, Jane I. Pernes, Xiongtao Ruan, Jorge Huete‐Carrasco, Carissa C. W. Wong, Jiahe Lu, Juma Ward, Giulia Toti, Alan J. Hedges, Simon J. Dovedi, Robert F. Murphy, David J. Morgan, Christoph Wülfing
Abstract
T lymphocytes with tumor cell spheroids in vitro induced a similar phenotype, supporting a critical role of direct T cell-tumor cell contact. Diminished engagement of PD-1 within the tumor, but not acute ex vivo blockade, partially restored cell couple maintenance and killing. PD-1 thus contributes to the suppression of TIL function by inducing a state of impaired subcellular organization.
Topics & Concepts
Cytotoxic T cellTumor cellsCancer researchCell biologyChemistryBiologyIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research