Reckoning apigenin and kaempferol as a potential multi-targeted inhibitor of EGFR/HER2-MEK pathway of metastatic colorectal cancer identified using rigorous computational workflow
Abhilasha Sharma, Sonam Sinha, Pooja Rathaur, Jaykant Vora, Prakash C. Jha, Kaid Johar, Rakesh Rawal, Neeta Shrivastava
Topics & Concepts
ApigeninKRASEGFR inhibitorsColorectal cancerKaempferolTrametinibCancer researchPharmacologyDocking (animal)MedicineKinaseChemistryMAPK/ERK pathwayEpidermal growth factor receptorCancerFlavonoidInternal medicineBiochemistryAntioxidantNursingColorectal Cancer Treatments and StudiesMelanoma and MAPK PathwaysComputational Drug Discovery Methods