P-glycoprotein Substrate Assessment in Drug Discovery: Application of Modeling to Bridge Differential Protein Expression Across In Vitro Tools
Na Li, Priyanka Kulkarni, Akshay Badrinarayanan, Adey Kefelegn, Raffi Manoukian, Xingwen Li, Bhagwat Prasad, Matthew Karasu, William J. McCarty, Charles G. Knutson, Anshul Gupta
Topics & Concepts
P-glycoproteinEffluxIn vitroCell cultureIn vivoProteomicsCell biologyBiologyChemistryMolecular biologyBiochemistryMultiple drug resistanceGeneticsBiotechnologyAntibioticsGeneDrug Transport and Resistance MechanismsProtein Interaction Studies and Fluorescence AnalysisHIV/AIDS drug development and treatment